| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366066 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
A series of diazepinylbenzoic acid derivatives were synthesized and tested in the inhibition assay of the transactivation of RXR. Oral treatment of cyano derivatives (16f) was found to show anti-diabetic and anti-obesity effects in KK-Ay mice.
Graphical abstractA series of diazepinylbenzoic acid derivatives were synthesized and tested in the inhibition assayof the transactivation of RXR. Oral treatment of cyano derivatives showed anti-diabetic and anti-obesity effects in KK-Ay mice.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Junichi Sakaki, Masashi Kishida, Kazuhide Konishi, Hiroki Gunji, Atsushi Toyao, Yuki Matsumoto, Takanori Kanazawa, Hidefumi Uchiyama, Hiroaki Fukaya, Hironobu Mitani, Yoshie Arai, Masaaki Kimura,