| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366067 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
Synthesis and structure–activity relationship of RXR antagonists employing a diazepinylbenzoic acid scaffold are described. Of those antagonists, sulfonamide derivatives (6v and 6w) reveal a high antagonistic activity and good pharmacokinetic properties.
Graphical abstractSynthesis and structure–activity relationship of RXR antagonists employing a diazepinylbenzoic acid scaffold are described. The sulfonamide derivatives were found to reveal a high antagonistic activity and good pharmacokinetic properties.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Junichi Sakaki, Kazuhide Konishi, Masashi Kishida, Hiroki Gunji, Takanori Kanazawa, Hidefumi Uchiyama, Hiroaki Fukaya, Hironobu Mitani, Masaaki Kimura,