| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366073 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
2,5,5-Trisubstituted oxazolones were identified as potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The synthesis, structure–activity relationship and metabolic stability of these compounds are presented.
Graphical abstractCompounds of general formula 1 were found to be potent inhibitors of 11β-HSD1. Synthesis, structure–activity relationship and metabolic stability of these compounds are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lori Sutin, Sören Andersson, Lars Bergquist, Victor M. Castro, Eva Danielsson, Stephen James, Martin Henriksson, Lars Johansson, Christina Kaiser, Katarina Flyrén, Meredith Williams,