| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366078 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
A series of 4-amino-6-piperazin-1-yl-pyrimidine-5-carbaldehyde oximes has been discovered and developed as potent FLT3 tyrosine kinase inhibitors. The series exhibited potent antiproliferative activity against both an FLT3 ITD-mutated human leukemic cell line as well as a wild-type FLT3 BaF3 expressed cell line. The structure–activity relationship of this class of compounds is described.
Graphical abstractA series of 4-amino-6-piperazin-1-yl-pyrimidine-5-carbaldehyde oximes has been discovered and developed as potent FLT3 tyrosine kinase inhibitors. The series exhibited potent antiproliferative activity against both a FLT3 ITD-mutated human leukemic cell line as well as a wild-type FLT3 BaF3 expressed cell line.Figure optionsDownload full-size imageDownload as PowerPoint slide
