| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366081 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
Biphenylic ester derivatives, designed by using a ‘soft-drug’ approach, proved to possess good binding properties toward cannabinoid CB1 and CB2 receptors and, at the same time, their metabolically labile ester portion would promote a rapid systemic inactivation. This may constitute a possible solution to the psychotropic side effects encountered when cannabinoids are therapeutically employed as local analgesic or antiglaucoma agents.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
F. Minutolo, M.G. Cascio, I. Carboni, T. Bisogno, G. Prota, S. Bertini, M. Digiacomo, M. Bifulco, V. Di Marzo, M. Macchia,