Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1366084 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
A series of 11 simple phylloquinone derivatives, each lacking the extended phytyl side chain but featuring H-bond donor amides at one or both peri positions, were prepared and some salient physical properties were measured. A correlation between both IR frequency and NMR peak position, as indicators of internal H-bond strength, and the quinone half-wave reduction potential, was observed. These data are consistent with the prevailing hypothesis that quinone carbonyl H-bonding in general, and stronger H-bonds in particular, favorably bias the endogenous quinone’s electrochemical potential toward easier reduction.
Graphical abstractPeri-amide-substituted naphthoquinones were synthesized and their reduction potentials, N–H IR and N–H 1H NMR absorptions were recorded.Figure optionsDownload full-size imageDownload as PowerPoint slide