| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366088 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
The objective of this report is to introduce the novel concept of utilizing sulfenamides as prodrugs for compounds containing an NH-acidic functionality, particularly weakly acidic amide-type functionalities (amides, ureas, carbamates, etc.). Included are the syntheses and physicochemical characterizations of some model sulfenamides to illustrate the promise of this new prodrug technology.
Graphical abstractThe objective of this report is to introduce the novel concept of utilizing sulfenamides as prodrugs for compounds containing an NH-acidic functionality, particularly weakly acidic amide-type functionalities.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Victor R. Guarino, Veranja Karunaratne, Valentino J. Stella,