| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366092 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
Highly potent, selective, and bioavailable inhibitors of human, mouse, or rat cathepsin S are described. The key structural features combine a sulfonyl moiety attached to a large group in P2 and a small substituent in P3.
Graphical abstractThe Merck Frosst Centre for Therapeutic Research, 16711 Trans Canada Highway, Kirkland, Qué., Canada H9H 3L1.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
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Authors
Jacques Yves Gauthier, W. Cameron Black, Isabelle Courchesne, Wanda Cromlish, Sylvie Desmarais, Robert Houle, Sonia Lamontagne, Chun Sing Li, Frédéric Massé, Daniel J. McKay, Marc Ouellet, Joël Robichaud, Jean-François Truchon, Vouy-Linh Truong,