Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1366097 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
Breast cancer, a leading cause of mortality in women, warrants the development and biological evaluation of new anticancer agents. A novel series of thiopyridine triazine derivatives was synthesized and investigated in the human breast cancer cell line, MDA-MB-468. SM40, the most potent derivative, induced a G2/M arrest and apoptosis with a possible involvement of p53. The cytotoxicity of SM40 was also examined against the NCI 60 cell line panel and its potency was rationalized using molecular modeling. Results suggest that SM40 is a promising cytotoxic agent.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Soma Mandal, Gervais Bérubé, Éric Asselin, Iqbal Mohammad, Vernon J. Richardson, Atul Gupta, Saroj K. Pramanik, Arthur L. Williams, Sanat K. Mandal,