| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366099 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A dumbbell-shaped circular oligonucleotide containing topoisomerase I-binding sites and two mismatched base pairs in its sequence has been designed and synthesized. Our further studies demonstrate that this particularly designed oligonucleotide displays an IC50 value of 9 nM in its inhibition on the activity of human topoisomerase I, a magnitude smaller than that of camptothecin, an anticancer drug currently in clinical use.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xinming Li, Magdeline Tao Tao Ng, Yifan Wang, Xiaoqian Liu, Tianhu Li,