Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1366181 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A new series of steroid-based 1,2,4-trioxanes 7a–f, 8a–f and 9b–e have been synthesized and evaluated for their antimalarial activity against multi-drug resistant Plasmodium yoelii in Swiss mice by oral route. The biological activity shows a strong dependence on the size and the nature of the steroidal side chain. Pregnane-based trioxanes 8a–f show better activity profile than trioxanes 7a–f and 9b–e, derived from cholesterol and tigogenine, respectively.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chandan Singh, Upasana Sharma, Gunjan Saxena, Sunil. K. Puri,