Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1366183 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
An activation study of the human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes VII and XIV using a small library of natural/non-natural amino acids and aromatic/heterocyclic amines is reported. hCA VII was efficiently activated by l-/d-His, dopamine and serotonin (KAs of 0.71-0.93 μM). The best hCA XIV activators were histamine (KA of 10 nM), l-Phe, l-/d-His and 4-amino-l-Phe (KAs of 0.24-2.90 μM). In view of the significant expression levels of CA VII and CA XIV in the brain, selective activation of these isoforms may be useful when developing pharmacologic agents for the management of major disorders such as epilepsy and Alzheimer's disease.
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Authors
Daniela Vullo, Alessio Innocenti, Isao Nishimori, Andrea Scozzafava, Kai Kaila, Claudiu T. Supuran,