Synthesis and antitumour activity of new tiazofurin analogues bearing a 2,3-anhydro functionality in the furanose ring

This paper describes a divergent de novo synthesis of 2-(2,3-anhydro-β-dribofuranosyl)thiazole-4-carboxamide (2′,3′-anhydro-tiazofurin) and the corresponding α- and β-homo-C-nucleosides, as well as evaluation of their antitumour activities in vitro.

Graphical abstractNovel tiazofurin derivatives, 2′,3′-anhydro-tiazofurin (2) and the corresponding β-(3) and α-(17) homo-C-nucleosides, have been synthesized and evaluated for their in vitro antitumour activity.Figure optionsDownload full-size imageDownload as PowerPoint slide