Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1366193 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
Several analogues of the potent anthelmintic praziquantel were prepared with variation in the aromatic ring. The biological activity of these analogues was evaluated and compared against known analogues. Amination of the ring was tolerated while other variations were not. These results have important implications for drug development for schistosomiasis.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Fiona Ronketti, A. Venkata Ramana, Xia Chao-Ming, Livia Pica-Mattoccia, Donato Cioli, Matthew H. Todd,