| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366194 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A series of 5-benzylidene-1,2-dihydro-2,2,4-trimethyl-5H-1-aza-6-oxa-chrysenes was synthesized and profiled for their ability to act as selective glucocorticoid receptor modulators (SGRMs). The synthesis and structure–activity relationships for this series of compounds are presented.
Graphical abstractA series of 5-benzylidene-1,2-dihydro-2,2,4-trimethyl-5H-1-aza-6-oxa-chrysenes were synthesized and profiled for their ability to act as selective glucocorticoid receptor modulators (SGRMs). The synthesis and structure–activity relationships for this series of compounds are presented.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Robert J. Ardecky, Andrew R. Hudson, Dean P. Phillips, John S. Tyhonas, Charlotte Deckhut, Thomas L. Lau, Yongkai Li, Esther A. Martinborough, Steven L. Roach, Robert I. Higuchi, Francisco J. Lopez, Keith B. Marschke, Jeffrey N. Miner,