Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1366199 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
We describe the synthesis and protozoocidal evaluation of a series of diazabicycles based on benzotropolone ethers. Several of the compounds, which can be obtained through a high-yielding hetero Diels–Alder reaction using simple and readily available starting materials, have in vitro activities against Trypanosoma cruzi and Leishmania donovani that are comparable to, and in some cases better than, those of currently used chemotherapies.
Graphical abstractThe synthesis and protozoocidal evaluation of a series of endocyclic hydrazines based on benzotropolone ethers is described.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Alexander Khrizman, Jason S. Moulthrop, Susan Little, Hayley Wharton, Vanessa Yardley, Guillermo Moyna,