| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366208 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
The discovery and optimization of a novel class of potent CCR3 antagonists is described. Details of synthesis and SAR are given together with some ADME properties of selected compounds. An optimal balance between activities, physicochemical properties, and in vitro metabolic stability was reached by the proper choice of substituents.
Graphical abstractThe discovery and optimization of a novel class of potent CCR3 antagonists is described. Details of synthesis and SAR are given.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Cécile Pégurier, Philippe Collart, Pierre Danhaive, Sabine Defays, Michel Gillard, Frédéric Gilson, Thierry Kogej, Patrick Pasau, Nathalie Van Houtvin, Marc Van Thuyne, BerendJan van Keulen,