| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366219 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
The identification of a potent series of IKK-β selective inhibitors based on an imidazothienopyrazine template and the oral efficacy of one such analog (22j) in the LPS-induced TNF-α release mouse model are described.
Graphical abstractThe identification of a potent series of IKK-β selective inhibitors based on an imidazothienopyrazine template and the oral efficacy of one such analog (22j) in the LPS-induced TNF-α release mouse model are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Makonen Belema, Amy Bunker, Van N. Nguyen, Francis Beaulieu, Carl Ouellet, Yuping Qiu, Yunhui Zhang, Alain Martel, James R. Burke, Kim W. McIntyre, Mark A. Pattoli, Connie Daloisio, Kathleen M. Gillooly, Wendy J. Clarke, Patrick J. Brassil,