| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366224 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
Three 9,10-di-O-(−)-camphanoyl-7,8,9,10-tetrahydro-benzo[h]chromen-2-one (7-carbon-DCK) analogs (3a–c) were synthesized and evaluated for inhibition of HIV-1 replication in H9 lymphocytes. All three new carbon bioisosteres of the anti-HIV lead DCK showed anti-HIV activity. Compound 3a had an EC50 value of 0.068 μM, which was comparable to that of DCK in the same assay. The preliminary results indicated that 7-carbon-DCK analogs merit attention as potential HIV-1 inhibitors for further development into clinical trials candidates.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yang Wang, Shao-Xu Huang, Peng Xia, Yi Xia, Zheng-Yu Yang, Nicole Kilgore, Susan L. Morris-Natschke, Kuo-Hsiung Lee,