| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366226 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
Analogs of PGE2 with introduction of diene groups at the ω-side chain have been synthesized and evaluated for their binding affinity for EP2 and EP4 receptors. An optimized analog (compound 9b) showed high potency and selectivity for the EP4 receptor over other known receptors.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yufang Xiao, Gian Luca Araldi, Zhong Zhao, Nadia Brugger, Srinivasa Karra, David Fischer, Elizabeth Palmer,