Antimicrobial activity of rationally designed amino terminal modified peptides

Series of short amino terminal modified cationic peptides were designed and synthesized. All of the synthesized compounds were tested against gram-positive as well as gram-negative bacterial strain. Some of the compounds exhibit potent antibacterial activity and no hemolytic activity even at high dose level (1000 μg/mL) in mammalian erythrocytes was observed.

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