| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366231 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
High throughput screening identified a phenoxyacetic acid scaffold as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish a compound with functional potency for inhibition of human eosinophil shape change and oral bioavailability in the rat.
Graphical abstractHigh throughput screening identified a phenoxyacetic acid scaffold 3 as a novel CRTh2 receptor antagonist chemotype. Optimisation furnished compound 6b, which showed functional potency for inhibition of human eosinophil shape change and oral bioavailability in the rat.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
David A. Sandham, Clive Aldcroft, Urs Baettig, Lucy Barker, David Beer, Gurdip Bhalay, Zarin Brown, Gerald Dubois, David Budd, Louise Bidlake, Emma Campbell, Brian Cox, Brian Everatt, David Harrison, Catherine J. Leblanc, Jodie Manini, Rachael Profit,