| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366235 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A series of indane acetic acid derivatives were prepared which show a spectrum of activity as insulin sensitizers and PPAR-α and PPAR-δ ligands. In vivo data are presented for insulin sensitizers with selectivity for PPAR-δ over PPAR-α.
Graphical abstractA novel series of indane acetic acid molecules are insulin sensitizers and have selectivity for PPAR-δ agonist activity over PPAR-α.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Philip Wickens, Chengzhi Zhang, Xin Ma, Qian Zhao, John Amatruda, William Bullock, Michael Burns, Louis-David Cantin, Chih-Yuan Chuang, Thomas Claus, Miao Dai, Fernando Dela Cruz, David Dickson, Frederick J. Ehrgott, Dongping Fan, Sarah Heald,