Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1366238 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A number of compounds bearing a quaternary ammonium moiety were found to be antagonists with nanomolar binding affinity for the chemokine receptor-2. The structure–activity relationships in the series are described herein along with some detailed characterization of the interesting compounds.
Graphical abstractA number of compounds bearing a quaternary ammonium moiety were found to be antagonists with nanomolar binding affinity for the chemokine receptor-2. The structure–activity relationships in the series are described herein along with some detailed characterization of the interesting compounds.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Bharat Lagu, Chrissy Gerchak, Meng Pan, Cuifen Hou, Monica Singer, Ravi Malaviya, Michele Matheis, Gil Olini, Druie Cavender, Michael Wachter,