Article ID Journal Published Year Pages File Type
1366239 Bioorganic & Medicinal Chemistry Letters 2007 5 Pages PDF
Abstract

Bioassay-guided fractionation of methanol extract of sea cucumber Actinopyga lecanora led to the isolation of a new triterpene glycoside (1), along with two known glycosides holothurin B (3) and holothurin A (4). The structure has been elucidated on the basis of extensive 2D NMR spectroscopic analysis. The saponin (3) showed in vitro antifungal activity against all the twenty fungal test isolates including ATCC strain and was found to be most effective against Trychophyton mentagrophytes and Sporothrix schenckii, MIC range of 1.56 μg/ml.

Graphical abstractIsolation and structure elucidation of a novel triterpene glycoside, along with two known saponin and in vitro antifungal activity.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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