Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1366386 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
An intramolecular radical cyclization reaction of 4-bromo-3-arylisoquinolines 11a–c allowed the efficient synthesis of 11-methylindenoisoquinolines 2a–c. 5-(2-Aminoethylamino)indeno[1,2-c]isoquinolin-11-one 4 was also prepared in the convenient manner. The synthesized compounds were tested in vitro for cytotoxicity and DNA-topoisomerase 1 (top 1) inhibitory activity. The dramatic enhancement of top 1 inhibitory activity of 4 was explained by a docking study using the FlexX program.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Won-Jea Cho, Quynh Manh Le, Hue Thi My Van, Kwang Youl Lee, Bok Yun Kang, Eung-Seok Lee, Sang Kook Lee, Youngjoo Kwon,