| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366389 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
Structure–activity relationship studies are described, which led to the discovery of novel selective estrogen receptor modulators (SERMs) for the potential treatment of uterine fibroids. The SAR studies focused on limiting brain exposure and were guided by computational properties. Compounds with limited impact on the HPO axis were selected using serum estrogen levels as a biomarker for ovarian stimulation.
Graphical abstractSAR studies are described, which led to the discovery of novel SERMs for the treatment of uterine fibroids.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Timothy I. Richardson, Scott A. Frank, Minmin Wang, Christian A. Clarke, Scott A. Jones, Bai-Ping Ying, Dan T. Kohlman, Owen B. Wallace, Timothy A. Shepherd, Robert D. Dally, Alan D. Palkowitz, Andrew G. Geiser, Henry U. Bryant, Judith W. Henck,