Synthesis and SAR studies of potent imidazopyridine anticoccidial agents

Diaryl imidazo[1,2-a]pyridine derivatives, such as 6a and 7i, have been synthesized and found to be potent inhibitors of parasite PKG activity. The most potent compounds are the 7-isopropylaminomethyl analog 6a and 2-isopropylamino analog 7i. These compounds are also fully active in in vivo assay as anticoccidial agents at 25 ppm in feed.

Graphical abstractDiaryl imidazo[1,2-a]pyridine derivatives bearing N-alkyl amino substituents have been synthesized and evaluated as highly potent Et-PKG inhibitor and efficacious anticoccidial agents.Figure optionsDownload full-size imageDownload as PowerPoint slide