Article ID Journal Published Year Pages File Type
1366408 Bioorganic & Medicinal Chemistry Letters 2007 5 Pages PDF
Abstract

Synthesis, in vitro biological evaluation, and structure–activity relationships of a biaryl cannabinoid mimetic 2 are reported. Variations in the substitution pattern yielded a number of agonists with low nanomolar affinity. Replacing the phenol group by a methyl morpholino acetate group led to compound 28, a 500-fold selective CB2 receptor agonist.

Graphical abstractA series of novel-substituted biaryl cannabinoid mimetics was synthesized and their biological activity determined.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
, , , , ,