Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1366408 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
Synthesis, in vitro biological evaluation, and structure–activity relationships of a biaryl cannabinoid mimetic 2 are reported. Variations in the substitution pattern yielded a number of agonists with low nanomolar affinity. Replacing the phenol group by a methyl morpholino acetate group led to compound 28, a 500-fold selective CB2 receptor agonist.
Graphical abstractA series of novel-substituted biaryl cannabinoid mimetics was synthesized and their biological activity determined.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Karin Worm, Q. Jean Zhou, Gabriel J. Stabley, Robert N. DeHaven, Roland E. Dolle,