| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366413 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
Fifty-two C-glycosides were synthesized and their in-vitro antiproliferative activity screened against human cervical carcinoma (HeLa) and osteosarcoma (HOS) cell lines. Nine of them had growth inhibitions (GI50 values) below 10 μM, the C-glucopyranoside 38 being the most active against HeLa (5.4 μM) and the dichlorocyclopropyl derivative 42 against HOS (1.6 μM). Some preliminary structure–activity relationships were established.
Graphical abstractFifty-two C-glycosides were synthesized and their in-vitro antiproliferative activity against human cervical carcinoma (HeLa) and osteosarcoma (HOS) screened, showing significant activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Carlos A. Sanhueza, Carlos Mayato, Rubén P. Machı´n, José M. Padrón, Rosa L. Dorta, Jesús T. Vázquez,