Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1366417 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
It is well known that both acute and chronic autoimmune inflammatory disorders arise following a breakdown in control of neutrophil activation and recruitment. In the search for new anti-inflammatory agents, we synthesized some new 2-phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives and tested them in vitro in order to evaluate their ability to interfere with human neutrophil functions. All tested compounds showed strong inhibition of fMLP-OMe-induced chemotaxis, although they appeared unable to block degranulation and the fMLP-OMe-induced respiratory burst, and were inactive in binding experiments.
Graphical abstractWe report here the synthesis of title compounds and their evaluation on neutrophil activation and recruitment.Figure optionsDownload full-size imageDownload as PowerPoint slide