| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366425 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A series of isoxazole derivatives were synthesized and their antagonistic activities against LPA stimulation on both LPA1/CHO cells and rHSC cells were evaluated. Among them, 3-(4-{4-[1-(2-chloro-cyclopent-1-enyl)-ethoxycarbonylamino]-isoxazol-3- yl}-benzylsulfanyl)-propionic acid (34) showed the most potent activities.
Graphical abstractA series of isoxazole derivatives were synthesized and their antagonistic activities against LPA stimulation on both LPA1/CHO cells and rHSC cells were evaluated. Among them, 3-(4-{4-[1-(2-chloro-cyclopent-1-enyl)-ethoxycarbonylamino]-isoxazol-3- yl}-benzylsulfanyl)-propionic acid (34) showed the most potent activities.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Takashi Yamamoto, Koichi Fujita, Sayaka Asari, Akira Chiba, Yuka Kataba, Koji Ohsumi, Naoko Ohmuta, Yuko Iida, Chiori Ijichi, Satoshi Iwayama, Naoyuki Fukuchi, Masataka Shoji,