Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1366426 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
A small series of derivatives of the alkaloid naamidine A was synthesized and tested in vitro for their ability to inhibit mitogenesis in BaF/ERX cells. Replacement of the imidazole core with a thiazole was found to have only a minor effect on potency, and the 4-methoxybenzyl substituent of the natural product was shown to be unnecessary for activity.
Graphical abstractThe syntheses of deletion analogues and thiazole analogues of naamidine A (1) are reported, together with data indicating inhibition of EGF- and IL3-dependent mitogenesis.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nicholas Aberle, Jenny Catimel, Edouard C. Nice, Keith G. Watson,