| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366429 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
We report here new chemical series acting as antagonists of melanin-concentrating hormone receptor 1 (MCHR-1). Synthesis and structure-activity relationships are described leading to the identification of compounds with optimized in vitro pharmacological and in vitro ADME profiles. In vivo activity has been demonstrated in animal models of food intake and depression.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Fabrice Balavoine, Patrice Malabre, Thierry Alleaume, Astrid Rey, Valérie Cherfils, Olivier Jeanneton, Sophie Seigneurin-Venin, Frédéric Revah,