Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1366538 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
γ-Secretase is a key enzyme involved in the production of β-amyloid peptides which are believed to play a critical role in the onset and progression of Alzheimer’s disease (AD). As such, inhibition of γ-secretase has been an attractive approach to AD therapy. In this paper, the design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as γ -secretase inhibitors are described.
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Related Topics
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Organic Chemistry
Authors
Tao Guo, Huizhong Gu, Doug W. Hobbs, Laura L. Rokosz, Tara M. Stauffer, Biji Jacob, John W. Clader,