Synthesis and structure–activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1

A series of 4-hydroxy-4-phenylpiperidines have been synthesized and bind to the nociceptin receptor with high affinity. The synthesis and structure–activity relationships at the N-1 and C-4 are described.

Graphical abstractA series of 4-hydroxy-4-phenylpiperidines have been synthesized and bind to the nociceptin receptor with high affinity. The synthesis and structure–activity relationships at the N-1 and C-4 hydroxy are described.Figure optionsDownload full-size imageDownload as PowerPoint slide