Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1366550 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A series of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) were examined in which the pendant imidazole moiety was replaced to improve selectivity for IGF-1R inhibition over cytochrome P450 (CYP). Synthesis and SAR of these compounds is presented.
Graphical abstractA series of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) were examined in which the pendant imidazole moiety was replaced to improve selectivity for IGF-1R inhibition over cytochrome P450 (CYP). Synthesis and SAR of these compounds is presented.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Upender Velaparthi, Peiying Liu, Balu Balasubramanian, Joan Carboni, Ricardo Attar, Marco Gottardis, Aixin Li, Ann Greer, Mary Zoeckler, Mark D. Wittman, Dolatrai Vyas,