Article ID Journal Published Year Pages File Type
1366555 Bioorganic & Medicinal Chemistry Letters 2007 4 Pages PDF
Abstract

Dideoxy-epigallocatechin gallate (DO-EGCG) (2), a simplified analog of naturally occurring EGCG (1), was efficiently prepared by directly introducing a ketone group at C3 and successive reduction to the sec-alcohol with 2,3-cis stereochemistry. Compound 2 showed potent anti-influenza virus activity, indicating that the hydroxyl substituents on the A-ring are not crucial for anti-influenza virus activity.

Graphical abstractDideoxy-epigallocatechin gallate (DO-EGCG) (2), a simplified analog of naturally occurring EGCG, was efficiently prepared. Compound 2 showed potent anti-influenza virus activity.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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