Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1366555 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
Dideoxy-epigallocatechin gallate (DO-EGCG) (2), a simplified analog of naturally occurring EGCG (1), was efficiently prepared by directly introducing a ketone group at C3 and successive reduction to the sec-alcohol with 2,3-cis stereochemistry. Compound 2 showed potent anti-influenza virus activity, indicating that the hydroxyl substituents on the A-ring are not crucial for anti-influenza virus activity.
Graphical abstractDideoxy-epigallocatechin gallate (DO-EGCG) (2), a simplified analog of naturally occurring EGCG, was efficiently prepared. Compound 2 showed potent anti-influenza virus activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Takumi Furuta, Yasuo Hirooka, Ayako Abe, Yusuke Sugata, Mitsuru Ueda, Kouki Murakami, Takashi Suzuki, Kiyoshi Tanaka, Toshiyuki Kan,