| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366566 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
A methylenebis(sulfonamide) linked NAD analogue has been designed to circumvent the metabolically unstable, ionic nature of the natural pyrophosphate linkage. This NAD analogue is assembled through two Mitsunobu reactions of a methylenebis(sulfonamide) linker with two protected nucleosides. A 2,4-dimethoxybenzyl group is used as a sulfonamide protective group, which allows facile removal under mildly acidic conditions. This NAD analogue inhibits IMPDH at low micromolar concentration.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Liqiang Chen, Guangyao Gao, Laurent Bonnac, Daniel J. Wilson, Eric M. Bennett, Hiremagalur N. Jayaram, Krzysztof W. Pankiewicz,