| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366685 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
We have previously reported a novel class of tetrahydroindazoles that display potency against a variety of Gram-positive and Gram-negative bacteria, potentially via interaction with type II bacterial topoisomerases. Herein are reported SAR investigations of this new series. Several compounds possessing broad-spectrum potency were prepared. Further, these compounds exhibit activity against multidrug-resistant Gram-positive microorganisms equivalent to that against susceptible strains.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
John J.M. Wiener, Laurent Gomez, Hariharan Venkatesan, Alejandro Santillán Jr., Brett D. Allison, Kimberly L. Schwarz, Shirin Shinde, Liu Tang, Michael D. Hack, Brian J. Morrow, S. Timothy Motley, Raul M. Goldschmidt, Karen Joy Shaw, Todd K. Jones,