Article ID Journal Published Year Pages File Type
1366698 Bioorganic & Medicinal Chemistry Letters 2007 4 Pages PDF
Abstract

Analogs of immunomodulatory glycolipid OCH (2) were prepared and minimum structure requirement to exhibit equivalent profiles was disclosed. Analogs bearing non-linear hydrocarbon chain in the phytosphingosine moiety (18, 19) were shown for the first time to possess comparable cytokine inducing profile to 2. Molecular modeling of 2/hCD1d complex based on the crystal structure of α-GalCer (1)/hCD1d complex is also described.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
, , , , , , , , , , ,