Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1366698 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
Analogs of immunomodulatory glycolipid OCH (2) were prepared and minimum structure requirement to exhibit equivalent profiles was disclosed. Analogs bearing non-linear hydrocarbon chain in the phytosphingosine moiety (18, 19) were shown for the first time to possess comparable cytokine inducing profile to 2. Molecular modeling of 2/hCD1d complex based on the crystal structure of α-GalCer (1)/hCD1d complex is also described.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tetsuya Toba, Kenji Murata, Kyoko Nakanishi, Bitoku Takahashi, Naohiro Takemoto, Minako Akabane, Takashi Nakatsuka, Seiichi Imajo, Takashi Yamamura, Sachiko Miyake, Hirokazu Annoura,