Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1366702 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Further structure–activity relationships of a novel series of fungal efflux pump inhibitors with respect to potentiation of the activity of fluconazole against strains of C. albicans and C. glabrata over-expressing ABC-type efflux pumps are systematically explored. Rat protein binding and pharmacokinetics of selected analogues are reported.
Graphical abstractFurther structure–activity relationships of a novel series of fungal efflux pump inhibitors with respect to potentiation of the activity of fluconazole against strains of Candida albicans and Candida glabrata over-expressing ABC-type efflux pumps are systematically explored. Rat protein binding, hepatocyte stability, and pharmacokinetics of selected analogues are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide