| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366709 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
A series of adamantyl amide 11β-HSD1 inhibitors has been discovered and chemically modified. Selected compounds are selective for 11β-HSD1 over 11β-HSD2 and possess excellent cellular potency in human and murine 11β-HSD1 assays. Good pharmacodynamic characteristics are observed in ex vivo assays.
Graphical abstractThe synthesis and biological activity of a series of adamantyl amide 11β-HSD1 inhibitors represented by 5 is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Scott P. Webster, Peter Ward, Margaret Binnie, Eilidh Craigie, Kirsty M.M. McConnell, Karen Sooy, Andy Vinter, Jonathan R. Seckl, Brian R. Walker,