Synthesis and in vitro cytotoxicity of novel lipophilic (diamine)platinum(II) complexes of salicylate derivatives

Novel lipophilic (diamine)platinum(II) complexes of salicylate derivatives as the leaving groups were synthesized and characterized by elemental analysis, FAB+-MS, FT-IR, and 1H NMR spectroscopy. Most of the resulting platinum complexes had high solubility in organic solvents such as ethanol, acetone, and ether, and had right partition coefficient suited to be encapsulated in liposomes. The pertinent complexes were evaluated for their in vitro cytotoxicity against A549 human lung carcinoma and SGC-7901 human gastric carcinoma cell lines. They showed better cytotoxic activity than carboplatin and oxaliplatin.

Graphical abstractSix novel (diamine)platinum(II) complexes of salicylate derivatives were prepared and their in vitro cytotoxicity as well as the liposolubility were determined. The results showed that the salicylate derivatives significantly enhanced both liposolubility and cytotoxicity of the platinum complexes.Figure optionsDownload full-size imageDownload as PowerPoint slide