| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366809 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
New 4-anilidopiperidine analogues in which the phenethyl group of fentanyl was replaced by several aromatic ring-contained amino acids (or acids) were synthesized to study the biological effect of the substituents on μ and δ opioid receptor interactions. These analogues showed broad (47 nM–76 μM) but selective (up to 17-fold) binding affinities at the μ opioid receptor over the δ opioid receptor, as predicted from the message-address concept.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yeon Sun Lee, Joel Nyberg, Sharif Moye, Richard S. Agnes, Peg Davis, Shou-wu Ma, Josephine Lai, Frank Porreca, Ruben Vardanyan, Victor J. Hruby,