| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366811 | Bioorganic & Medicinal Chemistry Letters | 2007 | 8 Pages |
Abstract
The design, synthesis, and SAR of a series of substituted spirohydantoins are described. Optimization of an in-house screening hit gave compounds that exhibited potent binding affinity and functional activity at MCH-R1.
Graphical abstractThe design, synthesis, and SAR of a series of substituted spirohydantoins are described. Optimization of an in-house screening hit gave compounds that exhibited potent binding affinity and functional activity at MCH-R1.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Martin W. Rowbottom, Troy D. Vickers, Junko Tamiya, Mingzhu Zhang, Brian Dyck, Jonathan Grey, David Schwarz, Christopher E. Heise, Michael Hedrick, Jenny Wen, Hui Tang, Hua Wang, Andrew Fisher, Anna Aparicio, John Saunders, Val S. Goodfellow,