| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366820 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
The high-affinity choline transporter (CHT1) system is an attractive target for the development of positron emission tomography (PET) biomarkers to probe brain, cardiac, and cancer diseases. An efficient and convenient synthesis of new radiolabeled CHT1 inhibitors [11C]hemicholinium-3 and [18F]hemicholinium-3 by solid-phase extraction (SPE) technique using a cation-exchange CM Sep-Pak cartridge has been well developed. The preliminary evaluation of both tracers through biodistribution studies in 9L-glioma rats has been performed, and the uptakes in the heart and tumor were observed, while very low brain uptake was seen.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Synthesis and biodistribution of new radiolabeled high-affinity choline transporter inhibitors [11C]hemicholinium-3 and [18F]hemicholinium-3](/preview/png/1366820.png "First Page Preview: Synthesis and biodistribution of new radiolabeled high-affinity choline transporter inhibitors [11C]hemicholinium-3 and [18F]hemicholinium-3")
Authors
Qi-Huang Zheng, Mingzhang Gao, Bruce H. Mock, Shuyan Wang, Toshihiko Hara, Rachid Nazih, Michael A. Miller, Tim J. Receveur, John C. Lopshire, William J. Groh, Douglas P. Zipes, Gary D. Hutchins, Timothy R. DeGrado,