| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366822 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
To study drug-receptor interactions, new thio-derivatives of salvinorin A, an extremely potent natural κ-opioid receptor (KOR) agonist, were synthesized. Obtained compounds were examined for receptor binding affinity. Analogs with the same configuration at carbon atom C-2 as in natural salvinorin A showed higher affinity to KOR than their corresponding epimers.
Graphical abstractTo study drug-receptor interactions, new thio-derivatives of salvinorin A, an extremely potent natural κ-opioid receptor agonist, were synthesized and examined for receptor binding affinity.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ruslan V. Bikbulatov, Feng Yan, Bryan L. Roth, Jordan K. Zjawiony,