| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366833 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
A series of N-substituted analogs based upon the spiropiperidine core of 1 was synthesized and exhibited high binding affinity to the nociceptin (NOP) receptor. The selectivities against other known opioid receptors were determined.
Graphical abstractA series of N-substituted analogs based upon the spiropiperidine core of 1 was synthesized and exhibited high binding affinity to the nociceptin (NOP) receptor. The selectivities against other known opioid receptors were determined.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
John P. Caldwell, Julius J. Matasi, Hongtao Zhang, Ahmad Fawzi, Deen B. Tulshian,