| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1366836 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
The design, synthesis, biophysical and biochemical evaluation is presented of a new series of benzylamino-substituted acridines as G-quadruplex binding telomerase inhibitors. Replacement of the previously reported anilino substituents by benzylamino groups results in enhanced quadruplex interaction, and for one compound, superior telomerase inhibitory activity.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Cristina Martins, Mekala Gunaratnam, John Stuart, Vaidahi Makwana, Olga Greciano, Anthony P. Reszka, Lloyd R. Kelland, Stephen Neidle,